The monkeypox virus has mutated at a far faster rate than would normally be expected and likely underwent a period of 'accelerated evolution,' a new study suggests.
, meaning that the current monkeypox strain should have really only accumulated a handful of mutations since it first started circulating in 2018.
Historically, monkeypox is transmitted from person to person by close skin contact with open skin lesions, bodily fluids, contaminated material or respiratory droplets coughed into the air. Many of the mutations identified by the researchers also carry telltale clues that they may have emerged due to the virus's contact with the human, specifically a family of the virus-fighting enzymes called APOBEC3. These enzymes attack viruses by forcing them to make mistakes when they copy their genetic code, an act which usually causes the virus to break apart.
. It may be that these sorts of battles happened repeatedly and caused the virus to pick up many mutations in a short span of time, the researchers theorized.It's possible that the virus has been circulating in humans, at low levels, since then, picking up a slew of new mutations through its battles with enzymes.
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