Methotrexate is not associated with testicular toxicity, so therapy can be safety started in men pursuing parenthood, a small study finds.
is not associated with testicular toxicity, so therapy can be safety started in men pursuing parenthood, a small study finds.Lack of evidence regarding MTX's effect on sperm quality has resulted in inconsistent recommendations for men actively pursuing parenthood.
Researchers enrolled 20 men aged 18 years or older with an immune-mediated inflammatory disease who were about to begin MTX therapy and 25 healthy men as controls. Participants provided semen samples prior to beginning MTX therapy and 13 weeks after beginning therapy.Also evaluated whether MTX polyglutamates could be detected in sperm of seminal fluid, as a secondary outcome.Found no significant differences in conventional semen parameters, sperm DNA damage, or male reproductive endocrine axis between the MTX group and controls.
The concentration of MTX polyglutamates is low in both sperm and seminal fluid and is particularly low in sperm."Therapy with MTX can be safely started or continued in men diagnosed with an IMID [immune-mediated inflammatory disease] and with an active wish to become a father," the authors write.
Argentina Últimas Noticias, Argentina Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
Expert Shares What Not to Do When You See a Snake After Being Bitten 50 TimesA reptile expert explained what exactly not to do when you see a snake in the midst of documenting himself getting bitten more than 50 times.
Leer más »
Tori Spelling and Dean McDermott Will Not Divorce, Source SaysDean McDermott announced on Saturday, June 17, that he and Tori Spelling had separated before deleting the post — exclusive details
Leer más »
It’s bizarre when we rely on jokesters — not journalists — for accurate reportingThe Justice Department has arrested Mr. Trump because he is Mr. Biden’s main political opponent. This fits with the administration’s ongoing 30-month prosecution of more than 1,000 Trump supporters.
Leer más »
Army’s vaunted new combat vehicle may be a tank (or maybe not)One of the Army's most hotly anticipated new combat vehicles certainly looks like a tank. It is covered with protective armor, runs on tracks, and features a powerful 105mm main gun. But when is a tank not a tank? When it's an M-10 Booker combat vehicle.
Leer más »
Facts matter: Trump indictment was real, not part of a conspiracyIn this week's Facts Matter column, Bob Oswald explores claims that the indictment of former President Donald Trump was just a show, the judge assigned to his case was photographed at a Trump rally, wildfires in Canada were purposely set and more.
Leer más »
Lots of Hiring, but Not So Much WorkingWorkers are putting in fewer hours—but that doesn’t mean their employers are gearing up for layoffs
Leer más »