Key studies on melanoma and skin cancers were presented at ASCO22.
Key studies on melanoma and skin cancers presented at ASCO 2022 included refinements to neoaduvant therapies for melanoma and two promising agents in advanced disease, one in melanoma and one in Merkel cell carcinoma.
Dr Jeffrey Weber, of NYU Langone's Perlmutter Cancer Center, reports first on neoadjuvant studies in melanoma. He reviews survival data from the phase 2 PRADO trial, a study of personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in stage III melanoma. The study found that patients with partial pathologic responses had worse outcomes, suggesting that they might benefit from adjuvant systemic therapy.
Other neoaduvant studies discussed include the Neo Trio trial of pembrolizumab alone or in combination with dabrafenib + trametinib in resectableIn advanced disease, Dr Weber reviews data presented on two new therapies. He discusses a phase 2 trial of camrelizumab, an IgG4 antibody against PD-1, combined with apatinib and temozolomide for patients with advanced acral melanoma.
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