The compound in psychedelic mushrooms helped heavy drinkers cut back or quit entirely in the most rigorous test of psilocybin for alcoholism.
, published Wednesday in JAMA Psychiatry, is “the first modern, rigorous, controlled trial" of whether it can also help people struggling with alcohol, said Fred Barrett, a Johns Hopkins University neuroscientist who wasn't involved in the study.
While it’s not known exactly how psilocybin works in the brain, researchers believe it increases connections and, at least temporarily, changes the way the brain organizes itself. “There’s a possibility of really shifting in a relatively permanent way the functional organization of the brain,” Bogenschutz said.Patients described life-changing insights that gave them lasting inspiration, Bogenschutz said.
“The quantity was unacceptable and yet I couldn’t stop," she said. “There was no off switch that I could access.” Patients receiving psilocybin had more headaches, nausea and anxiety than those getting the dummy drug. One person reported thoughts of suicide during a psilocybin session.
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