Losing weight and lowering BMI may help people slow, delay, or even prevent the structural defects of knee OA. RheumTwitter MedTwitter
The authors created two groups of knees at baseline: the"incidence cohort" of 9,683 knees from 5,774 participants without OA structural defects and the"progression cohort" of 6,075 knees from 3,988 participants with OA structural defects . After 4-5 years, they determined OA incidence and progression .At baseline, the mean patient age in both groups was around 60, and around 60% of participants were female.
The adjusted odds ratio for overall structural defects in the incidence group was 1.05 and 1.05 in the progression group was. A 1-unit decrease in BMI was linked with a nearly 5% drop in odds of incidence and progression of knee OA, and a 5-unit decrease was linked with a more than 21% drop in odds of incidence and progression.
In the progression group, change in BMI was positively linked with overall structural defects as well as medial, but not lateral, joint space degeneration ."Previous research showed that weight loss helps reduce symptoms of knee osteoarthritis, such as pain and impaired physical function," said lead study author Zübeyir Salis, BEng, a PhD student in public health at the University of New South Wales, Kensington, Australia.
"BMI data at only two time points does not consider BMI fluctuations between those times," she added."Limited data were presented on physical activity levels, and most participants being White and elderly limited the generalizability of the results.
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