Long-term preservation of liver grafts brings ‘off-the-shelf’ organs closer
, who described the successful 1-year post-liver-transplant outcome of a patient who received a liver graft after 3 days of normothermic perfusion.
This is by far the longest clinical ex situ preservation ever published, and was achieved using a self-assembled machine containing an automated pump system for graft perfusion; membrane dialysis for waste-product removal and electrolyte, hematocrit and acid–base balance control; a continuous administration of nutritive and vasoactive drugs; an automated control of glucose levels by injection of insulin and glucagon; a fine regulation of portal venous oxygen saturation; and a mechanism for...
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