Lignocellulosic biomass is a renewable feedstock for 2nd-generation biomanufacturing. In particular, efficient co-fermentation of mixed glucose and xylose in lignocellulosic hydrolysates is a key issue in reducing product costs.
and 3-hydroxypropionic acid , owing to the enhanced supply of precursor acetyl-CoA and cofactor NADPH by rewiring the cellular metabolism of Ogataea polymorpha.The researchers realized co-utilization of glucose and xylose by introducing a hexose transporter mutant and xylose isomerase, and overexpressing the native xylulokinase to enhance xylose catabolism and import.
The engineered strain produced 7.0 g/L FFA from real lignocellulosic hydrolysates in shake flasks and 38.2 g/L FFA from simulated lignocellulose in a bioreactor. Furthermore, this superior cell factory was expanded for 3-HP production by a metabolic transforming strategy, obtaining the highest 3-HP titer of 79.6 g/L from simulated lignocellulose.and glucose without compromising native glucose metabolism and demonstrated the potential of O.
Argentina Últimas Noticias, Argentina Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
Cinema Day returns Aug. 27 with $4 movie tickets nationwideMore than 3,000 theaters participating as event returns for 2nd year.
Leer más »
Shohei Ohtani has torn UCL, won’t pitch again in 2023AL MVP frontrunner left start Wednesday after 2nd inning
Leer más »
‘We took strides:’ Alabama football provides 2nd scrimmage takeawaysThe Crimson Tide had its second scrimmage of the 2023 preseason last weekend.
Leer más »