For women with excessive menstrual blood loss, the contraceptive levonorgestrel 52 mg delivered via an IUD reduced monthly blood loss by more than 90% over six monthly cycles, a multicenter open-label study reports.
For women with excessive menstrual blood loss, the contraceptive levonorgestrel 52 mg delivered via an intrauterine device reduced monthly blood loss by more than 90% over six monthly cycles, a multicenter open-label study reports.
Mean baseline blood loss in the cohort ranged from 73 mL to 520 mL . Of 89 treated women with follow-up, participants had a median absolute blood-loss decreases of 93.3% at cycle three and 97.6% at cycle six. Median bleeding reductions at cycle six were similar between women with and without obesity at 97.6% and 97.5%, respectively, and between nulliparous and parous women at 97.0% and 98.1%, respectively .
According to Dr. Gray, the IUD approach has advantages over systemic treatment with oral medication."First, treatment is not user-dependent so the user doesn't have to remember to take it. In addition, because the medication is locally targeted in the uterus, it is more effective and there is less fluctuation and variability in drug levels than when taken orally."
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