Isolated nail psoriasis may be a sign of PsA MedTwitter RheumTwitter
The often-delayed diagnosis of isolated nail psoriasis , along with the possibility of a"reciprocal relationship" with psoriatic arthritis,"should serve as an impetus for dermatologists to improve their diagnostic accuracy," investigators said in a research letter. and"arthritis was most often diagnosed concurrently with NP," at a major nail referral center between Jan. 1, 2001, and Dec. 21, 2022, Michelle J.
The most frequent clinical dyad was onycholysis and pitting in 66% of patients, followed by onycholysis/nail thickening in 33% and onycholysis/splinter hemorrhage in 32%. The most common histologic features were parakeratosis in 79% and neutrophil infiltration in 48%, the investigators said. Psoriatic arthritis , a focus of the study, occurred in 10 of the 87 individuals with isolated NP. Considering this finding, and"the close proximity between the nail apparatus and joint, we hypothesize a reciprocal relationship, with nail unit inflammation precipitating PsA," Ms. Chang and associates wrote.
Senior author, Shari Lipner, MD, PhD, of the department of dermatology, Weill Cornell Medicine, New York, is a consultant for Ortho-Dermatologics, Hoth Therapeutics, and BelleTorus. Ms. Chang and the two other investigators had no conflicts of interest to declare.Image 1: J Am Acad DermatolCite this: Isolated Nail Psoriasis May Be a Sign of Psoriatic Arthritis -
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