In its first human trial, the experimental muvalaplin reduced vessel-clogging cholesterol-carriers at impressive rates.
Taking a new approach, drug developers are now targeting Lp's ability to form in the first place.
trial, Nicholls and his team put muvalaplin through its paces with 114 volunteers, involving a mix of sexes, races, and ages . A second group consisting of 59 healthy participants, who all had above normal plasma levels of Lp, were then given a placebo,Within just 24 hours after the first dose, blood plasma levels of Lp dropped. The amount of reduction depended on the dose, reaching up to 65 percent for some patients over the course of the trial.
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