Thousands of Americans who shared their DNA for science are about to learn if they have some particularly worrisome genes
FILE - People stand by the All of Us Mobile Education and Enrollment Center at the Community Health Center on State Street in Meriden, Conn., May 13, 2019. Thousands of Americans who shared their DNA for science are about to learn something in return: if they harbor some problematic genes. It's part of a massive National Institutes of Health project to unravel how people's genetics, environments and habits interact to mold their health.
All of Us is an unprecedented effort to reduce health disparities and end today’s one-size-fits-all care. Researchers aim to track 1 million people from all walks of life for at least a decade to better understand the complex combinations of factors that determine why one sibling gets sick and not another, or why a cure for one patient fails in another.
“I kind of shudder to think about what could happen if I hadn’t known this,” said Rachele Peterson, an NIH employee participating in the study. The knowledge “allows you to take charge,” said Peterson, who plans to discuss options with her own doctor such as increased breast cancer screening or whether to consider precautionary ovary removal.
But there's a lot more to learn. For example, the vast majority of disease-linked genes were discovered by studying people of European ancestry. Very different variants may play a bigger role for other ancestries, said Baylor College of Medicine genetics expert Eric Venner.
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