Both teams are 7-6 and in the thick of the AFC playoff race. The Titans have a two-game lead in the AFC South while the Chargers are battling for one of the final two spots.
Henry will be facing a Chargers defense allowing 5.40 yards per carry. That's the highest average since the merger and the seventh-highest since the league started tracking rushing statistics in 1933, according to Sportradar.
"You can't let good running backs get started. It doesn't matter what their style is. If they can get started within the play, then they're going to have a chance to be successful," coach Brandon Staley said."You have to go attack, and you have to go play team defense and tackle the guy with more than one guy.Even though most of the attention is on Henry, Chargers running back Austin Ekeler is also expected to be a factor.
"It is a balancing act there of trying to do as much as you can and work the things as much as you can, but when you are banged up, your body can only do so much. It is not just myself. That is everybody on this team," said Tannehill, who has been limited due to an ankle injury."You can't worry too much about what is happening in front of you or around you.
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