Researchers report a gene therapy approach that appears to prevent conception in female cats with no apparent side effects.
. Nearly 1 million are euthanized each year in overcrowded shelters in the United States alone. Spay/neuter surgeries can help, but the approach isn’t feasible for large-scale sterilization campaigns.
That changed when an unusual pair of scientists came together. David Pépin, a reproductive biologist at Massachusetts General Hospital, spent his early career researching antimüllerian hormone , which is produced by follicles in the ovary that give rise to eggs. When, in one experiment, he amped up the expression of the hormone in female mice, their ovaries stopped forming follicles, sterilizing the animals.
One open question is how long the extra AMH will stick around. The introduced gene doesn’t become part of the cat’s muscle cell DNA, so it’s possible that it will disappear over time as muscle cells regenerate. Pépin notes that AMH levels did decrease over the course of the study, but that they remained elevated in all of the treated cats, including one followed for 5 years.
Pépin and Swanson are continuing to monitor the treated cats, closely following their health and behaviors. But the Michelson foundation likes what it sees so far. The organization, which plans to help commercialize any viable product, will be meeting with the U.S. Food and Drug Administration next month to map out larger safety and efficacy studies.
Argentina Últimas Noticias, Argentina Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
Say Hello To 33 TikTok-Famous Beauty Products You'll Want To Add To Your RoutineIncluding viral products that can scrub away dead skin, remove makeup and leave your hair feeling silky smooth.
Leer más »
Duchenne muscular dystrophy gene therapy approval rests on surrogate biomarker dataNature Medicine explores the latest translational and clinical research news, with a delayed FDA decision on Sarepta’s adeno-associated virus gene therapy SRP-9001.
Leer más »
tripleS ACID EYES drop 'Cherry Gene' visualizer MV | allkpoptripleS ACID EYES have dropped their visualizer music video for 'Cherry Gene'.In the MV, tripleS ACID EYES go on a dynamic…
Leer más »
2024 Peugeot 3008 Interior Revealed With A 21-Inch Screen | Carscoops2024 Peugeot 3008 Interior Revealed With A 21-Inch Screen car auto cars
Leer más »
Revolution in Pet Sterilization: Gene Therapy Offers Long-Term Contraception for CatsResearch study’s findings offer a potential alternative to surgical spaying. Currently, there are no contraceptives capable of producing permanent sterilization in companion animals. Spaying, the surgical removal of the ovaries and uterus, is the most widely used strategy to control unwanted repr
Leer más »