It's estimated that half of all people in the world are infected with Helicobacter pylori, a bacterium associated with increased risk for gastric ulcers and gastriccancer.
The article and accompanying editorial were published March 30 inFor this study, Yoshiaki Usui, MD, PhD, of the RIKEN Center for Integrative Medical Sciences in Yokohama, Japan, and colleagues analyzed samples from 10,426 patients with gastric cancer as well as 38,153 control samples from a Japanese biobank.
They found that germline pathogenic variants in nine genes were associated with the risk for gastric cancer. The genes wereThe pathogenic germline variants in these nine genes were associated with homologous recombination, which involves an exchange of nucleotide sequences between two similar or identical DNA molecules that occurs during meiosis and during repair of double-strand DNA breaks.
"Our results suggest that in persons known to carry a pathogenic variant in a homologous-recombination gene, evaluation and eradication of"It is remarkable that pathogenic variants in homologous-recombination genes drive tumorigenesis only in the context ofinfection," write Anne Müller, PhD, and Jiazhuo He, MD, from the University of Zurich, Switzerland, in an accompanying editorial.
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