The team hopes to conduct clinical trials next year (2023). Some patients have tried everything to cure their knee pain, including over-the-counter painkillers, physical therapy, and steroid injections. However, their pain persists. Osteoarthritis, which affects 867 million individuals globally
A gel-based cartilage replacement for sore knees has been created by Duke researchers. It is stronger and more long-lasting than the real thing.Some patients have tried everything to cure their knee pain, including over-the-counter painkillers, physical therapy, and steroid injections. However, their pain persists.
Sparta Biomedical is currently developing and testing implants made of the material on sheep. Researchers are preparing to start human clinical trials next year. According to Wiley, the cellulose fibers provide the gel strength when stretched, much like the collagen fibers in natural cartilage. The polyvinyl alcohol helps it return to its original shape. The end product is a Jello-like substance that is 60% water and surprisingly strong.
By increasing the crystal content, the researchers were able to produce a gel that can withstand five times as much stress from pulling and nearly twice as much squeezing relative to freeze-thaw methods. Their method of attachment involves cementing and clamping the hydrogel to a titanium base. This is then pressed and anchored into a hole where the damaged cartilage used to be. Tests show the design stays fastened 68% more firmly than natural cartilage on bone.
In wear tests, the researchers took artificial cartilage and natural cartilage and spun them against each other a million times, with a pressure similar to what the knee experiences during walking. Using a high-resolution X-ray scanning technique called micro-computed tomography , the scientists found that the surface of their lab-made version held up three times better than the real thing.
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