Letermovir was shown to be just as effective as valganciclovir in preventing CMV in kidney transplant recipients in new study published in JAMA; results prompt additional FDA approval for this indication.
, according to the editorialists, leading patients to potentially stop taking the drug early or lower the dosage. November 2021 for the treatment of post-transplant CMV that is resistant to other drugs in transplant recipients aged 12 years or older who weigh at least 35 kg .The new study was a phase 3, randomized, active-controlled, double masked, double-dummy, noninferiority trial comparing letermovir with valganciclovir and included 589 participants across 94 international locations.
Patients in the letermovir group were also less likely to develop early disease: the letermovir group had no cases of CMV disease compared with 1.7%, or five cases, developing in the valganciclovir group, at week 28. "The surprising absence of resistance sequence variants or breakthrough disease in this prevention trial is a critical and somewhat unexpected finding," Raglow and Kaul write in their editorial. in the letermovir group compared with the valganciclovir group , meaning drug discontinuation due to adverse events is less likely with letermovir.
Argentina Últimas Noticias, Argentina Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
FDA OKs Injectafer for Iron Deficiency Anemia in HFThis new indication for ferric carboxymaltose injection marks the first FDA approval of an intravenous iron replacement therapy for adult patients with heart failure, the company said.
Leer más »
A CMV Patient Journey: Educating, Screening, Diagnosing, and Implementing Team-Based Care📍 CMVAwareness: Learn from a CMV patient's journey and how you can educate, screen, diagnose, and implement team-based care. MedEd CME MedTwitter
Leer más »
Oklahoma board OKs taxpayer-funded religious schoolOklahoma Attorney General Gentner Drummond had warned the board that such a decision clearly violated the Oklahoma Constitution. “The approval of any publicly funded religious school is contr…
Leer más »
Atlanta City Council OKs $67M for Cop City as Thousands Showed Up in OppositionDespite thousands protesting, Atlanta City Council approves $30M in additional funding for Cop City, a massive police training facility. The total cost is now $67M, more than double the original estimate.
Leer más »
Texas Senate committee OKs bill letting state arrest illegal border crossingsLegal experts believe if the bill is passed and signed into law it will likely face court challenges.
Leer más »
LA Council OKs music, alcohol sales under al fresco dining planThe vote passed the City Council's Planning and Land Use Management Committee and will now go before the full Council for a vote.
Leer más »