Amid the surge of respiratory syncytial virus, Barney Graham—a former scientist at the U.S. National Institute of Allergy and Infectious Diseases—reflects on how his team’s work was key to the apparent success of Pfizer’s RSV vaccine and others.
.] It’s extremely gratifying for me to see how basic research can lead to products if it all makes sense biologically. It’s a fun time. Probably a little over half, and virtually everyone is infected by their second year of life and everyone is definitely affected by the third year of life. The most severe diseases are very young, under 6 months of age.
Q: How do you compare vaccinating the mother to vaccinating the infant? And what do we know from studies that have vaccinated infants directly? Active immunization of young children has been complicated. The old vaccine in the mid ’60s caused vaccine-enhanced disease that really prevented and delayed vaccine development for many, many decades. There are other products coming along that are going to be targeting the 6- to 12-month-old infant, but the current vaccines have just not gotten there.
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