Proposals to expand domestic breeding of primates for research overlook several ethical, scientific and safety woes.
in preparation for what appeared to be an imminent expansion of U.S.-based breeding programs, with more funding promised on the way.by the National Academies of Sciences, Engineering, and Medicine concluded that supply of monkeys for research is “at a crisis point.” The report, entitled, “State of the Science and Future Needs for Nonhuman Primate Model Systems,” was also commissioned by the NIH in response to a congressional inquiry and calls from animal research enthusiast groups.
Instead of some innovative, out-of-the-box solutions expected from the NSA report, the same age-old refrain advocating for more federal support to fund program enlargement seems to be the fix here. This markedly detracts from the originality of the report in proposing real, unrecycled solutions to the abuse and also unreliability issues of NHPs in medical research and testing.
The main challenge in drug development is the reliance on a misguided paradigm for modeling human diseases — a paradigm centered around artificial animal models that are neither predictive nor relevant. A close second is the inability to reproduce biomedical research data, dubbed in the field as the “reproducibility crisis,” which is attributed in large parts to, ironically, the use of animals in research. In 2014, Francis S.
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