Clinical, genomic and transcriptomic analyses of paired samples of synchronous bilateral female breastcancer identify associations between tumor concordance and immune infiltrates levels and response to neoadjuvant treatment FabienReyal JoshWaterfall
The cohort comprises 37 patients with sBBCs treated with neoadjuvant treatment with both immune infiltration and concordance status of the pair available. A.
Primary tumors are labelled PT, specimens with residual disease are labelled RD. Abbreviations: ER, estrogen receptor; intratumoral TIL, intratumoral tumor infiltrating lymphocytes; L, left; neg, negative; pCR, pathologic complete response; PR, progesterone receptor; PT, patient; R, right, RD, residual disease; str TIL, stromal tumor infiltrating lymphocytes; TNBC: triple negative breast cancer.
A. Tumor mutation profiles: Heatmap of somatic driver mutations ; B. Venn diagrams showing the number of mutations shared between the left and the right primary tumors of a same patient; C: Copy number alterations ; D: Mutational signatures profiles as published by Alexandrovare calculated using the deconstructSigs package.; E: Fishplots retracing phylogeny between left, right primary tumors. Abbreviations: L, left; R, right; RD, TNBC, triple negative breast cancer.
The stainings were performed in the in left, right, pre and post-NAC samples of a cohort of 6 patients . The images A to H show the same regions of tumors stained with the whole panel and focusing on an antibody . Markers of the panel #1 include - CD4 – CD8 – CD45RO – FOXP3 – CD20 – AE1/AE3, and markers of the panel #2 include CD68 – CD 163 – CD138 – CKIT – AE1/AE3.
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