Did gonorrhea give us grandparents? ucsandiego
The myelomonocytic receptor CD33 inhibits innate immune reactivity by extracellular V-set domain recognition of sialic acid -containing “self-associated molecular patterns” . We earlier showed that V-set domain-deficient-variant allele, protective against late-onset Alzheimer’s Disease , is derived and specific to the hominin-lineage. We now report multiple hominin-specific CD33 V-set domain mutations.
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© The Author 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.
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