🎧 How is post-infection IBS identified? What is the expected duration of the condition, and what are the available treatment options? Join expert physicians LinChangMD and mgrover_gi as they discuss. GastroTwitter
getting it more commonly. Patients who are hospitalized during infection or who have a greater severity of infection are also at higher risk. We do know some of these factors. There was also some interesting work looking at the effect of
— things like anxiety, depression, and suicide ideation. These factors were associated with an increased risk of development of postinfection.It shows the importance of the brain-gut axis and how there is an interplay and a dynamic process between them. You can have environmental factors like stress or anxiety, and they increase your risk when the insult is really in the gut or it started in the gut.
As far as treatments are concerned, there have not been a lot of clinical trials that have looked at postinfection IBS as a unique entity for enrollment, except for one recent study. Colleagues looked at glutamine, for example, and how that can influence symptoms in folks who have postinfection IBS. They measured their urinary excretion of sugars, which is an assay for intestinal permeability, and they selected for patients who had increased intestinal permeability.
You touched on something really important that you and I both learned from Doug Drossman, which is conveying information to the patients so they understand more about their condition. I like glutamine a lot. I've used that and also for patients with IBS with diarrhea not only postinfection because there were some original data showing it could work in that subgroup as well. I want to move on to post-COVID IBS, which is newer.
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