Drs Sparks and Kumar go behind the scenes and discuss the preparation, surgery, and outcome of the pig-to-human kidney xenotransplantation at the UofAlabama.
, the Nobel Prize laureate who did all the work on vascular anastomosis. The fascinating part of the story is that when he did this transplant, the source organ was from a pig. The kidney was put in the right arm of a 48-year-old woman. After the anastomosis was done, he would examine the left antecubital space every day. On day 3, the anastomosis was thrombosed, and he thought it was just his terrible surgical technique. He repeated this experiment a second time.
in the recipient to accept these organs, how do you make the organ itself more human like? And so, in the process of doing that, along with the Gal knockout, which is the primary antigen insertion of protective genes that interfere with the coagulation cascade, another big modification was made. Complements are a huge part of this innate response humans have to anything foreign in them, and controlling the complement system became extremely important.
A lot of things had to happen to get to this point. We started almost 100 years ago. And now we're to the point where we want to give this a shot. Tell us about what happened and how you even get to the point where you can do this in a human. This is a brain-dead human. They're not alive. Can you tell us a bit more about how this occurred?Absolutely.
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