A systematic review using the Burden of Proof meta-analytic method found a significant harmful effect between high systolic bloodpressure and ischemicheartdisease. IHME_UW
). However, we observed that the uncertainty around estimates based only on data from RCTs was considerably larger than that based on data from the MRFIT trial and PSC study. Specifically, inclusion of data from the MRFIT study reduced the UI and modified BPRF and corresponding ROS. Based on a model including only RCT data, the BPRF value for IHD risk was 1.33 based on an SBP reference value of 120 mm Hg, which corresponds to a ROS of 0.28 and a star rating of three.
Our data-driven, meta-regression approach allowed us not only to compute the mean risk function across different study designs and SBP exposure rangesby relaxing conventional log-linear assumptions, controlling for bias and explicitly handling differences in exposure ranges across studies—but also to generate BPRF, which quantifies and accounts for between-study heterogeneity.
While it is true that the relationship between SBP and IHD is well known, as established by previous meta-analyses
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