For patients with chronic migraine, combination therapy with anti-CGRP monoclonal antibodies and onabotulinumtoxinA may be more effective than monotherapy, possibly owing to the synergistic mechanism of action of the two agents, a new study suggests.
may be more effective than monotherapy, possibly owing to the synergistic mechanism of action of the two agents, a new study suggests.
For the study, the investigators reviewed the electronic medical records of 194 patients who had been concurrently treated with anti-CGRP mAbs and onabot. Most were women; ages ranged from 36 to 65 years, and at baseline, they had been having an average of 28 monthly migraine days . Single-agent treatment is not sufficient for many patients. Data confirming the benefit of dual therapy will provide more evidence to insurance companies of the need for coverage.
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