Although patients and their family members long for effective treatments for dementia, high-quality evidence on the benefits of the drugs already available is lacking.
, and rivastigmine), as well as memantine, are prescribed to alleviate symptoms and delay disease progression in dementia. Given uncertainties about the benefits and adverse effects of these drugs in the long term and in severe dementia, the review sought to evaluate the effects of withdrawal or continuation of ChEIs or memantine, or both, in people with dementia — up to October 2020.
In summary, the results suggest the following conclusions about maintaining treatment with a cholinesterase inhibitor, compared with withdrawal:
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