New SciSignal research in rodents deciphers how infections with SARSCoV2 in the lungs generate systemic antiviral responses—and suggests that these responses may help limit the virus from spreading to other organs. COVID19
To investigate the impact that systemic IFN priming has on SARS-CoV-2 biology, we next sought to explore the consequences of dampening this biological process. Our approach involved the use of the immunosuppressant steroid dexamethasone to delay IFN priming, thus allowing us to assess how this early innate response may affect the outcome of infection.
Considering that COVID-19 often results in more severe symptoms among the elderly population, who also exhibit a diminished immune response , our subsequent efforts sought to investigate a possible correlation between SARS-CoV-2 dissemination and the nonpulmonary manifestations associated with severe disease. To this end, we administered SARS-CoV-2 intravenously to bypass the IFN priming event orchestrated by the lung and monitored the behavior of the virus thereafter.
Overall, our investigation sheds light on the possible mechanisms underlying the nonpulmonary manifestations of severe COVID-19. Here, we propose that, for healthy individuals, this systemic antiviral signaling protects tissues distal to the primary site of infection from the establishment of secondary infections.
Of the extrapulmonary consequences of COVID-19, kidney-associated diseases or pathologies are some of the most frequent ones in severe cases of COVID-19 . In this study, we identified some interesting features in the kidneys of infected animals that could be at the root of some of these complications.
This study leveraged hamsters to examine the relationship between SARS-CoV-2 biology and the host response. The findings suggest that, in healthy individuals, the virus is confined to the respiratory tract as a result of a system-wide antiviral response. Should this response be impaired in any way, SARS-CoV-2 can escape the airways and initiate productive infections in distal organs.
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