A research project carried out by the University of Bonn holds promise for the development of treatments for skin and gut disorders in the medium term. Scientists at the University of Bonn and the National University of Singapore have uncovered a novel intracellular 'smoke detector.' This sensor
have uncovered a novel intracellular “smoke detector.” This sensor alerts the cell of damage to the mitochondria – the cellular powerhouses that provide energy. Dysfunction of this sensor can lead to chronic skin conditions. The discovery may also have implications for the maintenance of healthy heart and intestinal function. The findings have recently been published in the journalEvery cell in the body has numerous sensors that monitor its function.
If the mitochondria are damaged, the NLRP10 “smoke detector” sounds the alarm and forms with other proteins into an inflammasome . Ultimately, this leads to the demise of the cell and its disposal. Credit: Kim S. Robinson/Skin Research Institute Singapore“This process is hugely important,” explains Latz, who is also the spokesperson for the Cluster of Excellence ImmunoSensation2 and a member of the Transdisciplinary Research Area “Life and Health” at the University of Bonn.
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