Nature research paper: Cancer aneuploidies are shaped primarily by effects on tumour fitness
Matrix of significantly recurring BISCUT peaks across 33 independent tumor types. Peaks are sorted by genomic location , with four distinct classes of peaks in dark red , light red , light blue , and dark blue . Tumor types are sorted and color-coded according to hierarchical clustering by Ward’s method .
Extended Data Fig. 6 Cells engineered with chr8p deletion for validation of genes in BISCUT selection peaks. Schematic for 8p deletion approach. Cells were transfected with a CRISPR targeting 8p just outside the centromere and with a linearized plasmid containing an artificial telomere, puromycin selection cassette, and 1 kilobase of sequence homologous to the 8p pericentromeric sequence. Puromycin selection was used to isolate cells with 8p replaced by the artificial telomere. ichorCNA output of ultra-low-pass whole genome sequencing data from five AALE cell clones with 8p disomy or 8p monosomy.
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