A research team including a UAB scientist has discovered how chronic pain causes depression and are looking into whether the drug ketamine may be helpful in alleviating it.
“Chronic pain is often comorbid with mood disorders, like depression and anxiety, which intensify patients suffering and are clinically difficult to treat,” said Dr. Li.
“Targeting Tiam1 to normalize the number and strength of neuron-neuron connection can relieve depressive symptoms in chronic pain patients,” said Li. In 2019 the FDA approved a nasal spray called Esketamine, which is derived from ketamine, to treat depression. It is the first new medication forLow doses of ketamine have successfully been used as anti-depressants in animals by blocking hypersensitivity from chronic pain, according to Li.
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