Big tech companies invest billions in health research. News feature from Paul Webster.
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Nature's Nano-Syringes: Harnessing Bacterial Machines for Next-Gen MedicineBacterial Injection System Delivers Proteins in Mice and Human Cells With further development, the programmable system could be used in a range of applications including gene therapy and cancer therapy. Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Re
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A Sleep Medicine Specialist Says These 7 Cooling Pillows Can Prevent Night SweatsThe best cooling are made of shredded memory foam, latex, or other cooling materials that wick away moisture and keep you sweat-free.
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It’s different for each person, but sometimes the best medicine is an extra pushIt’s different for each person, but sometimes the best medicine is an extra push to get outside, writes Alaska outdoors columnist Alli Harvey.
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Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial - Nature MedicineIn a randomized phase 2 trial, sotigalimab, a CD40 agonist, did not significantly improve overall survival in patients with previously untreated metastatic pancreatic cancer when combined with chemotherapy or with nivolumab and chemotherapy. Multi-omic exploratory analyses provide insights into immunologic features associated with clinical benefit.
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Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial - Nature MedicineIn a phase 2 trial, the combination of chemotherapy with durvalumab, an anti-PD-L1 antibody, exhibited promising clinical activity in patients with previously untreated, unresectable mesothelioma, with additional analyses providing insights into genomic and immunologic features potentially associated with response.
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Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i - Nature MedicineAnalyses from the COMBI-i trial evaluating PD-1, BRAF and MEK inhibition in patients with metastatic melanoma demonstrate high response rates and uncover molecular correlates of long-term treatment benefit. Trial led by AACR23 speaker Reinhard Dummer
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