The NIH stopped a clinical trial early after finding that daily statin medication, pitavastatin calcium, reduced cardiovascular disease risk in people living with HIV by 35%. The findings could lead to improved cardiovascular outcomes for this population using common cholesterol-lowering medicines.
A National Institutes of Health clinical trial was stopped early because a daily statin medication was found to reduce the increased risk of cardiovascular disease among people living with HIV in the first large-scale clinical study to test a primary cardiovascular prevention strategy in this population.
The REPRIEVE study is primarily supported by the National Institute of Allergy and Infectious Diseases and the National Heart, Lung and Blood Institute with additional funding from the NIH Office of AIDS Research. The study was conducted by the AIDS Clinical Trials Group . “The REPRIEVE study reflects the evolution of HIV science, and progress from focusing mostly on approaches to treat and control theto finding ways to improve the overall health of people living with HIV,” said acting NIAID Director Hugh Auchincloss, M.D. “These new data suggest that a common cholesterol-lowering medicine could substantially improve cardiovascular outcomes in people with HIV.”
The study’s DSMB met at planned intervals throughout the study to review safety and efficacy data. In its most recent meeting, the DSMB determined that the benefits of daily pitavastatin use outweighed any risks and recommended that the study terminate early, and that a full data collection be conducted across sites for final analysis. Study participants are being notified of the findings and will continue to be monitored for several months.
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