⭐Research highlight: Researchers used base editing — a type of CRISPR technology — to create a CARTcell product with potent activity in children with relapsed T cell acute lymphoblastic leukemia. NEJM
Most children with T cell acute lymphoblastic leukemia can be treated with standard therapies, but for those who relapse, the prognosis is very poor.
Although chimeric antigen receptor T cells have been used to treat B cell cancers, their use in T cell cancers is more complex; for example, therapeutic cells can eliminate each other because of their expression of the CAR target.
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