PhD Candidate in Quantitative Developmental Biology, Swiss Federal Institute of Technology Zurich.
The axolotl is an aquatic salamander renowned for its ability to regenerate its spinal cord, heart and limbs . These amphibians also readily make new neurons throughout their lives. In 1964, researchers observed that adult axolotls could regenerate parts of their brains , even if a large section was completely removed. But one study found that axolotl brain regeneration has a limited ability to rebuild original tissue structure.
This tool has been instrumental in understanding the types of cells that exist in the brains of animals. Scientists have used scRNA-seq in fish , reptiles , mice and even humans . But one major piece of the brain evolution puzzle has been missing: amphibians. We then put axolotl regeneration to the test by removing one section of their telencephalon. Using a specialized method of scRNA-seq , we were able to capture and sequence all the new cells at different stages of regeneration, from one to 12 weeks after injury. Ultimately, we found that all cell types that were removed had been completely restored.
Amphibians and human brainsAdding amphibians to the evolutionary puzzle allows researchers to infer how the brain and its cell types has changed over time, as well as the mechanisms behind regeneration.
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