Rhinovirus infection is associated with stimulating histamine-releasing factor and HRF-reactive immunoglobulin E for increasing severity of asthma and exacerbations. MedX
Immunological and quantitative mRNA assays support a pathogenesis role for histamine-releasing factor , its interaction with HRF-reactive immunoglobulin –E and rhinovirus inClinical data for healthy controls were compared with data from patients with asthma for three distinct cohorts recruited from programs located in Pittsburg, Boston, and Virginia
Cohorts differed primarily by total number of participants, median age, description of asthma severity, RV status, and longitudinal follow-up. Enzyme-linked immunoassay tests quantified for comparisons total IgE, IgGs, and IgG1 levels occurring in human sera samples and for HRF-reactive IgE, IgG1, and IgG2b in sera from mice inoculated with mouseAnti-IgE stimulation experiments characterized bronchoalveolar lavage cell supernatants for tryptase and PGD2 by ELISA and the mRNAs for tryptase and FCER1A
Effect of inoculated RV infections and/or house dust mite allergen on stimulating HRF secretion from respiratory epithelial cells and in vitro–grown lung BEAS-2B cells was evaluated by Western blots.HRF-reactive IgE and total IgE levels in serum were significantly higher from patients with severe asthma than from HCs and showed a rising trend as severity increased.
RV infection induced HFR secretions from both in vivo– and in vitro–grown respiratory epithelial cells and was associated with higher levels of HRF-IgE at the time of asthma exacerbations compared with after resolution.Inhibiting HRF and HRF-reactive IgE interactions"can be a preventative/therapeutic target" for severe and RV-induced exacerbated asthma conditions.
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