Aspirin use tied to lower risk for early colorectal cancer CRCSM
In patients with Lynch syndrome, the CAPP2 study showed that aspirin has a protective effect against colorectal cancer at 20 years follow-up.
The objective of the new study was to assess the association between regular aspirin or NSAID use at least twice weekly, with the risk of developing early-onset adenoma. The analysis is based on an evaluation of data from the Nurses' Health Study II of 32,058 women who had at least one colonoscopy before age 50 . High-risk adenomas included those that were at least 1 cm with tubulovillous/villous histology or high-grade dysplasia, or the presence of at least three adenomas.
With later-onset adenomas, risk reduction was confined primarily to large or multiple adenomas , but not adenomas of advanced histology .
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