They claim the genetically created creature will 'walk like a Woolly Mammoth, look like one, sound like one,' and 'inhabit the same ecosystem.'
CRISPR is an engineered cellular technology used for recognizing and cutting a specific code of DNA inside the nucleus. Once this DNA is cut, a laboratory modified version of DNA is inserted and reanneals the cut DNA by binding to the specific code. […]
In mammalian cells, such as an elephant or a Woolly Mammoth, CRISPR works with an enzyme called Cas9 to modify genes. A CRISPR-Cas9 complex will use a single guide RNA from CRISPR to guide and recognize a specific sequence of DNA, where the Cas9 molecule will cleave those strands that are complementary to the CRISPR sequence. This allows for the reinsertion of the laboratory engineered DNA. [...
Using software and recovered genetic samples, Church and his team have identified the key genetic differences between extant elephants, like the Asian and African elephants, and the Woolly Mammoth. Their plan is to insert reconstructed mammoth DNA into portions of the African elephant genome, creating an embryo that will incubate in a synthetic mammoth uterus, asInitially, Dr. Church envisioned implanting embryos into surrogate female elephants. But he eventually soured on the idea.
Instead, Dr. Church decided to make an artificial mammoth uterus lined with uterine tissue grown from stem cells. 'I'm not making a bold prediction this is going to be easy,' he said. 'But everything up to this point has been relatively easy. Every tissue we've gone after, we've been able to get a recipe for.'
The company claims that the reintroduction of a genetically created mammoth into the arctic could provide ecological and climate benefits by bringing back what's known as
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