Applied Molecular Transport stock sinks after placebo bests ulcerative colitis drug - San Francisco Business Times

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Applied Molecular Transport stock sinks after placebo bests ulcerative colitis drug - San Francisco Business Times
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$AMTI falls as ulcerative colitis trial fails and company seeks partner for late-stage study of same drug for chronic pouchitis

The signature drug from a Peninsula biotech company was bested in a mid-stage ulcerative colitis clinical trial by a placebo, according to top-line results, a result that at one point Friday sent the company's stock tumbling more than 60%.

More than 17% of 70 ulcerative colitis patients in the Phase II trial who received once-a-day AMT-101 had a"complete response," where all signs of the disease disappeared. The problem was that 20% of 35 patients who were given a placebo also had a complete response. "While we are disappointed with the top-line results, we are seeking to better understand the unexpectedly high placebo rate of clinical remission in this moderate-to-severe population," AMT Chief Medical Officer Dr.Kanwar added that AMT is"encouraged" by positive data of the same drug in patients with a condition known as chronic pouchitis. AMT is seeking a partner that would take AMT-101 into a late-stage study in that condition.

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