In an interim analysis of a first-in-human phase 1 trial of patients with neuroblastoma, highly pure GD2-specific CARNKT cells were well tolerated with no observed dose-limiting toxicities. ChildhoodCancerAwarenessMonth
The authors are grateful to M. Brenner, H. Heslop and personnel from the cGMP facility at the Center for Cell and Gene Therapy for manufacturing CAR-NKT cells; A. Sher, K. Kukreja and P. Srivaths; staff of the Flow Cytometry Core Laboratory of the Texas Children’s Cancer and Hematology Center; P. Saha for excellent technical assistance; and E. Chomsky, E. Kiner and H. Sharim for help with scRNA-seq.
Andras Heczey, Amy N. Courtney, Simon Robinson, Ka Liu, Mingmei Li, Nisha Ghatwai, Bin Liu, Cynthia N. Chauvin-Fleurence, Xin Xu, Ho Ngai, Erica J. Di Pierro & Leonid S. MetelitsaAndras Heczey & Leonid S. MetelitsaAndras Heczey, Olga Dakhova & Leonid S. MetelitsaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
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