Microbial molecules from soil, seawater and human bodies are among the planet’s least understood proteins.
Credit: ESM Metagenomic Atlas
“These are the structures we know the least about. These are incredibly mysterious proteins. I think they offer the potential for great insight into biology,” says Alexander Rives, the research lead for Meta AI’s protein team.— using a ‘large language model’, a type of AI that are the basis for tools that can predict text from just a few letters or words.
As a test case, they decided to wield their model on a database of bulk-sequenced ‘metagenomic’ DNA from environmental sources including soil, seawater, the human gut, skin and other microbial habitats. The vast majority of the DNA entries — which encode potential proteins — come from organisms that have never been cultured and are unknown to science.
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