Individuals suffering from Alzheimer's disease experience impairments in cognitive abilities, such as memory, as well as challenges with noncognitive functions, which can result in anxiety and depression. In a study published on April 6 in the journal Cell Stem Cell, researchers examined a process k
Researchers found that deep brain stimulation of new neurons generated through adult hippocampus neurogenesis improved cognitive and noncognitive functions in mouse models of Alzheimer’s disease. Activation of a small population of these new neurons in the supramammillary nucleus led to significant behavioral restoration and potential plaque removal, highlighting the potential for future targeted therapies for Alzheimer’s and related dementia.
“We were surprised to find that activating only a small population of adult-born new neurons was enough to make a significant contribution to these brain functions,” says senior author Juan Song, an associate professor at the Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease. Credit:This research used two distinct mouse models of Alzheimer’s. The investigators used optogenetics to stimulate the SuM and enhance AHN in Alzheimer’s mice. Theirhad shown that stimulation of the SuM could increase the production of new neurons and improve their qualities in normal adult mice.
To further understand the mechanism, they also analyzed the protein changes in the hippocampus of Alzheimer’s mice in response to activation of SuM-modified adult-born new neurons. They found several well-known protein pathways activated inside cells, including those known to be important for improved memory performance, as well as those that allow clearance of the plaques related to Alzheimer’s.
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