Food and Drug Administration scientists say that oral phenylephrine doesn't work for nasal decongestion, though the agency's final decision has yet to be made.
back then that oral phenylephrine might be ineffective, the advisory committee and FDA were ultimately convinced otherwise by the overall data as well as the arguments made by cold medicine makers, so the drug stayed put. However, the agency did state
that it might reassess the decision in the future once more research was concluded. In 2015, the FDA wasby researchers from the University of Florida to do just that, which has led to this new meeting. Since 2007, there have been several studies on the topic, including three large clinical trials. And it appears that the data nowadays is much more definitive. These large placebo-controlled trials have shownthat standard and even higher doses of oral phenylephrine relieve nasal decongestion. While the drug might have a decongestant effect when taken intranasally, other data cited by the FDA has found that our bodies barely absorb it when taken orally.
The FDA’s review is not the final word on the subject. It’s possible that the advisory committee will recommend once again that oral phenylephrine remains on shelves. But even if the panel does recommend that, the FDA can still choose to ignore their advice and pull the drug anyway.
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