A type of DNA computer that shows results through the motion of tiny beads could increase the parallel processing power of such machines 100-fold.
Previous designs have used fluorescent labels to show results and can only output tens of results simultaneously. They also require complex microscopes to read these findings.
“That’s the wild thing. You can convert the information from the DNA computational operation to the macroscopic world using a standard smartphone in just 15 minutes,” says Salaita.The team engineered “guide” DNA molecules onto the beads, which can bind to matching RNA molecules that are attached to the chip surface. When this occurs, the beads stay still, but when an enzyme called RNaseH is added to the chip, this enables the beads to roll by breaking the DNA-RNA complexes.
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