Unlike Narcan that's given by someone else after an overdose, the antibody would be given by a doctor before someone uses fentanyl. It has shown 30 days of overdose prevention in non-human testing.
The hope is that this would be another tool in the fight against fentanyl deaths.
"We're trying to get to high-risk individuals before they experience an overdose and provide a protective mechanism in the form of this antibody so fentanyl is rendered ineffective," Barrett said.The Santa Clara County Fentanyl Working Group's Dr. Rachel Sussman says there are other pre-overdose treatments for opioids, like vivitrol, and more study needs to be done before CSX-1004 goes receives full FDA approval.But, she says this could be helpful.
"We do have several tools already and I think one of our challenges is making sure that those existing tools are not underused," Sussman said. "But, another tool would never hurt. And, absolutely I think that the more things we have to offer patients the better."While the first round of human testing begins Tuesday, FDA approval would not come until late 2025 or early 2026.
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